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Science driven
results.

Compared directly to Synvisc-One,‡9 DUROLANE reduced pain more effectively.

In a Level 1 study, there was a significantly greater reduction in visual analog scale (VAS) pain scores at 3 and 6 months with DUROLANE compared to Synvisc-One (hylan G-F 20) (p<0.001).9

DUROLANE showed:

  • 41% lower VAS pain score at 6 months vs. Synvisc-One (hylan G-F 20).
  • Only DUROLANE mainained a significant reduction vs. baseline.

‡Some patients were treated with a three-injection Synvisc regimen. A three-injection Synvisc regimen is equivalent to one injection of Synvisc-One.
Synvisc and Synvisc-One are registered trademarks of Genzyme Biosurgery.

 

Clinically Equivalent to Five-Injection Hyaluronic Acid Therapy.14,17

In a Level 1 study, one injection of DUROLANE:

  • Produced pain reduction at 6 months that was noninferior to pain relief following five injections of the comparator hyaluronic acid.
    • 79% of DUROLANE-treated patients experienced improved pain control for up to 26 weeks§10
  • Choose convenience without compromise and get powerful results of a single-injection.

§Outcomes measured by WOMAC subscores. The primary outcome was the WOMAC pain responder rate, defined as at least 40% relative improvement and 5-point absolute improvement from baseline values at 12 weeks.

Compared directly to steroids injections,‖14 DUROLANE relieved pain longer.

In a Level 1 study:

  • DUROLANE was proven to be noninferior to steroid at 6 weeks.
  • Results favored DUROLANE for reduction in WOMAC pain, function and stiffness scores from weeks 12 to 26.
  • A significant reduction from baseline to week 26 in WOMAC pain scores was achieved with DUROLANE vs steroid.

‖Effect-sizes for WOMAC domains with 95% CIs during the blinded phase of the study.
The primary outcome was the WOMAC pain responder rate, defined as at least 40% relative improvement and 5-point absolute improvement from baseline values at 12 weeks.

 

Significantly Improved Quality of Life

A single injection of DUROLANE significantly improved all Knee and Osteoarthritis Outcome Score (KOOS) parameters in as early as 2 weeks, and the improvements persisted for up to 24 weeks.27