“We conclude that intra-articular hyaluronic acid is a useful intervention in patients with mild to moderate osteoarthritis of the knee, can produce sustained pain relief at 6 months, and can reduce the requirement for analgesia and antiinflammatory medication during this time.”

Full article available at Journal of Arthritis 

“Single-injection NASHA was well tolerated and, although there was no significant benefit versus saline control in the primary analysis, post-hoc analysis showed a statistically significant improvement in pain relief at 6 weeks among patients without clinical effusion at baseline.”

Article abstract available at PubMed.gov. 

“NASHA was not superior to placebo for the primary efficacy analysis. However, these data may be confounded by the inclusion of patients with osteoarthritis at other sites, as significant benefits over placebo were found among patients with osteoarthritis confined to the knee. Future trials of osteoarthritis that examine a local therapy might need to consider restricting the study population to those patients having osteoarthritis of only the signal joint.”

Full article available at Elsevier.

“The elimination kinetics of 131I-labelled NASHA from the human knee joint were described by three distinct phases, with half-times of 1.5 hours, 1.5 days and 4 weeks. Most likely, the last value reflects the true half-life of NASHA following intra-articular injection since the labelling method used causes minimal modification of hyaluronan.

Full article available at PubMed.gov


“Factors like a lower age of the patient and the involvement of a single joint influenced the referral of the patient to surgery. The administration of viscosupplementation delayed the time until the patient was finally referred to surgery.”

Full article available at Reumatologíca Cliníca.

“This study shows that single-injection NASHA was well tolerated and non-inferior to MPA [methylprednisolone acetate] at at 12 weeks. The benefit of NASHA was maintained to 26 weeks while that of MPA declined. An injection of NASHA at 26 weeks conferred long-term improvements without increased sensitivity or risk of complications.”

Full article available at Elsevier. 

“No safety concerns were raised in either the primary study or in the study extension. NASHA as an intra-articular therapyfor osteoarthritis of the knee appears to have an acceptable safety profile and thus merits further investigation regarding its long-term clinical efficacy.”

Article abstract available at SpringerLink

“We conclude that a single-injection of Durolane can reduce arthrosis associated knee pain sufficiently. Our data are comparable with those published in clinical studies using other hyaluronic acids. The effects of Durolane are delayed but more sustained compared to those found for glucocorticoids. Because of the single-injection, we see an advantage in using Durolane compared to other conventional hyaluronic acids and glucocorticoids.”

Article abstract available at PubMed.gov.