The DUROLANE Difference
Shown to significantly improve patient quality of life as early as 2 weeks after an injection, DUROLANE effectiveness has been proven in more clinical studies than any other single-injection hyaluronic acid knee therapy:20
DUROLANE has the highest reported molecular weight of any HA–1015 kDa.*43,46
*Based on theoretical calculations

Uniquely formulated for superior single-injection performance
Created using an innovative stabilizing technology, DUROLANE was purposefully designed to be a powerful, single-injection hyaluronic acid therapy.10
DUROLANE is a high-molecular-weight, nonavian hyaluronic acid, stabilized with a carefully controlled cross-linking process to increase residence time in the knee joint.10,15,33
Choose DUROLANE for longer-lasting results
- Total joint residence time of approximately 150 days based on a half-life of 30 days35,48
- A half-life of 30 days (approximately 4 weeks) in the knee joint in a single-injection treatment regimen35
- The longest reported half-life of any HA32-35
‡The clinical relevance of this information has not been determined.
