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Prescribing Information   |  OAKneePainRelief.com
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A powerful single-injection choice for knee osteoarthritis pain relief

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The DUROLANE Difference

Shown to significantly improve patient quality of life as early as 2 weeks after an injection, DUROLANE effectiveness has been proven in more clinical studies than any other single-injection hyaluronic acid knee therapy:20

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Greater reduction in knee pain vs. Synvisc-One®(hylan G-F 20)25

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Clinically equivalent to a 5-injection hyaluronic acid therapy13,24

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Longer-lasting knee pain relief vs. steroid injections11

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DUROLANE has the highest reported molecular weight of any HA–1015 kDa.*43,46

*Based on theoretical calculations

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Uniquely formulated for superior single-injection performance

Created using an innovative stabilizing technology, DUROLANE was purposefully designed to be a powerful, single-injection hyaluronic acid therapy.10

DUROLANE is a high-molecular-weight, nonavian hyaluronic acid, stabilized with a carefully controlled cross-linking process to increase residence time in the knee joint.10,15,33

Choose DUROLANE for longer-lasting results

  • Total joint residence time of approximately 150 days based on a half-life of 30 days35,48
  • A half-life of 30 days (approximately 4 weeks) in the knee joint in a single-injection treatment regimen35
  • The longest reported half-life of any HA32-35

‡The clinical relevance of this information has not been determined.

DUROLANE, GELSYN-3 and SUPARTZ FX are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g., acetaminophen. Risks include general knee pain and pain at the injection site.

View Use and Important Safety Information at: DUROLANE.com, GELSYN3.com, and SUPARTZFX.COM

Summary of Indications for Use:
DUROLANE is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g. acetaminophen.

Do not inject DUROLANE in patients with knee joint infections, skin diseases, or other infections in the area of the injection site. Do not administer to patients with known hypersensitivity or allergy to sodium hyaluronate preparations. Risks can include transient pain or swelling at the injection site.

DUROLANE has not been tested in pregnant or lactating women, or children.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
GELSYN-3 is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen). Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations. Do not inject GELSYN-3 into the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site.

GELSYN-3 is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

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