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References

  1. Tang T, Muneta T, Ju YJ, et al. Serum keratin sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats; protective effect of intraarticular hyaluronan injection. Arthritis Res Ther. 2008;10(1):R13. doi:10.1186/ar2363
  2. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, Lotz M, Amiel D. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol. 2000;27(7):1713-20.
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  6. Wang CT, Lin YT, Chiang BL, Lin YH, Hou SM. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthritis Cartilage. 2006;14(12):1237-47. doi:10.1016/j.joca.2006.05.009
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  8. Waddell DD, Kolomytkin OV, Dunn S, Marino AA. Hyaluronan suppresses IL-1ß-induced metalloproteinase activity from synovial tissue. Clin Orthop Relat Res. 2007;465:241-8. doi:10.1097/BLO.0b013e31815873f9
  9. Pavelka K, Uebelhart D. Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinovial®) vs. hylan G-F20 (Synvisc®) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study. Osteoarthritis Cartilage. 2011;19(11):1294-300. doi:10.1016/j.joca.2011.07.016
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  11. Leighton R, Åkermark C, Therrien R, et al. NASHA hyaluronic acid vs. methylprednisolone for knee osteoarthritis: a prospective, multi-center, randomized, non-inferiority trial. Osteoarthritis Cartilage. 2014;22(1):17-25. doi:10.1016/j.joca.2013.10.009
  12. Altman R, Lim S, Steen RG, Dasa V. Hyaluronic acid injections are associated with delay of total knee replacement surgery in patients with knee osteoarthritis: evidence from a large U.S. health claims database. PLoS One. 2015;10(12):e0145776. doi:10.1371/journal.pone.0145776
  13. DUROLANE [package insert]. Durham, NC: Bioventus LLC; 2019.
  14. GELSYN-3 [package insert]. Durham, NC: Bioventus LLC; 2017.
  15. Balazs EA, Denlinger JL. Viscosupplementation:a new concept in the treatment of osteoarthritis. J Rheumatol Suppl. 1993;39:3-9.
  16. SUPARTZ FX [package insert]. Durham, NC: Bioventus LLC; 2015
  17. Centers for Medicare & Medicaid Services. 2021 ASP Drug Pricing Files. Last updated December 10, 2021. cms.gov/medicare/medicare-part-b-drug-average-sales-price/2021-asp-drug-pricing-files
  18. Sutter Health. Help for arthritic knees. Accessed August 13, 2021. www.sutterhealth.org/services/orthopedic/non-surgical-treatment-knee-osteoarthritis
  19. Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis:a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46-54. doi:10.7326/M14-1231
  20. Krocker D, Matziolis G, Tuischer J, et al. Reduction of arthrosis associated knee pain through a single intra-articular injection of synthetic hyaluronic acid. Z Rheumatol. 2006;65(4):327-31. doi:10.1007/s00393-006-0063-2
  21. WebMD. What are NSAIDs for arthritis? Accessed August 14, 2021. Last updated December 4, 2020. www.webmd.com/arthritis/anti-inflammatory-drugs
  22. Sun SF, Hsu CW, Hwang CW, et al. Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests. Osteoarthritis Cartilage. 2006;14(7):696-701. doi.org/10.1016/j.joca.2006.01.010 *NOTE: SUPARTZ FX is referred to as Artzal in this publication.
  23. Arthritis Foundation. Arthritis by the numbers. Accessed August 14, 2021. Posted March 2019. www.arthritis.org/getmedia/e1256607-fa87-4593-aa8a-8db4f291072a/2019-abtn-final-march-2019.pdf
  24. Zhang H, Zhang K, Zhang X, et al. Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26-week non-inferiority trial comparing Durolane to Artz. Arthritis Res Ther. 2015;17(1):51. doi:10.1186/s13075-015-0557-x
  25. McGrath AF, McGrath AM, Jessop ZM, et al. A comparison of intra-articular hyaluronic acid competitors in the treatment of mild to moderate knee osteoarthritis. J Arthritis. 2013:2(1);1000108. doi:10.4172/2167-7921.1000108
  26. Arthritis Foundation. Osteoarthritis. Accessed September 3, 2021. www.arthritis.org/diseases/osteoarthritis
  27. Orthoinfo. Arthritis of the Knee. American Academy of Orthopaedic Surgeons. Arthritis of the knee. Last updated February 2021. https://orthoinfo.aaos.org/en/diseases–conditions/arthritis-of-the-knee/
  28. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Osteoarthritis. Last updated October 2019. niams.nih.gov/health-topics/osteoarthritis
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  30. Messier SP, Resnik AE, Beavers DP, et al. Intentional weight loss in overweight and obese patients with knee osteoarthritis:is more better? Arthritis Care Res (Hoboken). 2018;70(11):1569-75. doi:10.1002/acr.23608
  31. McAlindon TE, LaValley MP, Harvey WF, et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis:a randomized clinical trial. JAMA. 2017;317(19):1967-75. doi:10.1001/jama.2017.5283
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DUROLANE, GELSYN-3 and SUPARTZ FX are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g., acetaminophen. Risks include general knee pain and pain at the injection site.

View Use and Important Safety Information at: DUROLANE.com, GELSYN3.com, and SUPARTZFX.COM

Summary of Indications for Use:
DUROLANE is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g. acetaminophen.

Do not inject DUROLANE in patients with knee joint infections, skin diseases, or other infections in the area of the injection site. Do not administer to patients with known hypersensitivity or allergy to sodium hyaluronate preparations. Risks can include transient pain or swelling at the injection site.

DUROLANE has not been tested in pregnant or lactating women, or children.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
GELSYN-3 is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen). Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations. Do not inject GELSYN-3 into the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site.

GELSYN-3 is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

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