Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinvovial®) vs hylan G-F20 (Synvisc®) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study.
Journal: Osteoarthritis and Cartilage
Authors: Pavelka K, Uebelhart D.
Synovial (GELSYN-3) was found to be equivalent to higher molecular weight Synvisc in efficacy and safety. Although not statistically significant, there were fewer treatment-related adverse events were seen with Synovial (GELSYN-3).