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Prescribing Information   |  OAKneePainRelief.com
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A choice trusted around the world for knee osteoarthritis pain relief1

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SUPARTZ FX Hyaluronic Acid Therapy

With its proven effectiveness, affordability, excellent safety profile, and flexible dosing options, SUPARTZ FX is chosen worldwide as a preferred hyaluronic acid treatment to manage knee osteoarthritis:37

  • 410 million injections and more than 30 years of use worldwide37
  • More than 20 prospective clinical trials in the published literature41
  • Demonstrated safe with repeat injection cycles16

SUPARTZ FX targets knee osteoarthritis in 3 ways

Middel 1
Mechanical
Middel 5
Cellular
Middel 3
Biochemical

SUPARTZ FX MECHANISM OF ACTION

In targeting mechanical and cellular levels in animal models and biochemical levels in cell cultures, SUPARTZ FX inhibits IL-1β, MMP-3, and NO pathways, leading to reduced pain and inflammatory reactions, and protects nociceptors, which also reduces osteoarthritis knee pain.‡

‡Evidence obtained in preclinical studies. The clinical relevance of this information has not been determined

 

SUPARTZ FX Mechanism of Action Video

DUROLANE, GELSYN-3 and SUPARTZ FX are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g., acetaminophen. Risks include general knee pain and pain at the injection site.

View Use and Important Safety Information at: DUROLANE.com, GELSYN3.com, and SUPARTZFX.COM

Summary of Indications for Use:
DUROLANE is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g. acetaminophen.

Do not inject DUROLANE in patients with knee joint infections, skin diseases, or other infections in the area of the injection site. Do not administer to patients with known hypersensitivity or allergy to sodium hyaluronate preparations. Risks can include transient pain or swelling at the injection site.

DUROLANE has not been tested in pregnant or lactating women, or children.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
GELSYN-3 is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen). Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations. Do not inject GELSYN-3 into the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site.

GELSYN-3 is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

Summary of Indications for Use:
SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site.

Full prescribing information can be found in product labeling, or by contacting Bioventus Customer Service at 800-836-4080.

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